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KMID : 0369820070370050291
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Jorunal of Korean Pharmaceutical Sciences
2007 Volume.37 No. 5 p.291 ~ p.295
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SMEDDS (Self-MicroEmulsifying Drug Delivery System) As An Intraurethral Prostaglandin Delivery System
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Lee Sang-Kil
Jeon Sang-Ok
Kang Jae-Seon
Lee Jae-Hwi
Choi Young-Wook
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Abstract
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Prostaglandin was formulated as two self-microemulsifying drug delivery systems (SMEDDS) composed of Cremophor or Cremophor as a surfactant, ethanol as a cosurfactant and Labrafac as an oil to develop liquid preparation for the treatment of erectile dysfunction. In pseudo-ternary phase diagram, viscous gel area and microemulsion area were defined. In the measurement of viscosity, the viscosity of two formulations increased gradually upon the addition of water and it decreased from the water contents over 40%. With excessive water, the present systems formed a microemulsion spontaneously. From these results, rte could expect that the present liquid SMEDDS formulations might stay within the urethra in the viscous state when contacting the moisture of the urethra and can be easily eliminated by urination. In long-term stability study, we could select one formulation more stable at the shelf storage condition of .
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KEYWORD
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Erectile dysfunction, Intraurethral, Prostaglandin , SMEDDS, Self-emulsifying drug delivery system
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